學術論文

1. Jhao-Lin Fu, Shih-Chieh Lin, Pei-Ling Hsu, Tzu-Chien Lin, Yu-Jing Tai, Kai-Li Chang, Yu-Ting Ko, Bo-Wen Lin, Shaw-Jenq Tsai. Drug Resistance

UpdatesTargeting hypoxia-driven CARM1 overexpression overcomes oxaliplatin resistance and attenuates tumor malignancy in colorectal cancer. DrugResistance Updates (Accepted for publication) (SCI)(IF:21.7)

2. Pei-Hung Chang, Hong-Hwa Chen, Hung-Chih Hsu , Meng-Che Hsieh, Hao-Wei Teng, Yi-Hsin Liang, Jeng-Kai Jiang, Feng-Fan Chiang, Johnson Lin, Been-Ren Lin, Yao-Yu Hsieh, Tao-Wei Ke, Feng-Che Kuan, Wen-Shih Huang, Bo-Wen Lin, Yu-Yao Chang, Yu-Li Su, William Tzu-Liang Chen,    Chien-Kuo Liu and  Jaw-Yuan Wang. Optimizing third-line and beyond therapies for metastatic

colorectal cancer in Taiwan: an evidence-based consensus. Therapeutic advances in medical oncology. 2026 vol 18:1-18. (SCI)(IF:5.8)

3. Yi-Hsuan Huang, Shang-Yin Wu, Chung-Ta Lee, Bing-Syuan Chung, Peng-Chan Lin, Ren-Hao Chan, Po-Chuan Chen, Bo-Wen Lin, Meng-Ru Shen, Shang-Hung Chen , Yu-Min Yeh. Clinical and immunological implications of lymphocyte-

activation gene 3 expression in metastatic colorectal cancer. Cancer Immunology Immunother. 2026 Mar 3;75(4):93. (SCI)(IF:5.8)

4. Shih-Chieh Lin, Ya-Chuan Tsai, Jui-Lin Wang, Hsian-Jean Chin, Ching-Chin Tsai, Shin-Chih Lin, Yi-Syuan Lin, Bo-Wen Lin, Shaw-Jenq Tsai. Targeting NUDT21-mediated alternative polyadenylation of oncogenes ameliorates

colorectal cancer malignancy and metastasis. British journal of cancer. 2026 Aug;135(4):518-531. (SCI)(IF:7.8)

5. Er-Hsiang Yang, Nai-Yu Chen, Ching-Lan Cheng, Yu-Ching Chang, Po-Chuan Chen, Lu-Hsuan Wu, Jui-Wen Kang, Hsueh-Chien Chiang, Po-Jun Chen, Bo-Wen Lin, Hsin-Yu Kuo, Chiao-Hsiung Chuang. Evolution of surgical trends in

Crohn's disease during the biologic era: population-based cohort insights from Taiwan, a low-endemicity region. Intestinal Research. 2025 Nov 25. doi:10.5217/ir.2025.00003. (SCI)(IF:4.7)

6. Chih-Hsu Huang, Chun-Hsien Wu, Ren-Hao Chan, Chian-Hui Chen, Bo-Wen Lin, Chou-Ching K Lin. Transcutaneous auricular vagus nerve stimulationaccelerates postoperative ileus recovery by enhancing gastric motility complexity: A clinical study. Brain Stimulation. 2025 Jul-Aug; 18(4):1091-1093. (Corresponding author) (SCI)(IF:8.4)

7. Ching-Wen Huang, Chou-Chen Chen, Shih-Ching Chang, Yu-Yao Chang, Bo-Wen Lin, Hong-Hwa Chen, Yao-Yu Hsieh, Hung-Chih Hsu, Meng-Che Hsieh,Tao-Wei Ke, Feng-Che Kuan, Chih-Chien Wu, Wei-Chen Lu, Yu-Li Su, Yi-Hsin Liang, Joe-Bin Chen, Shuan-Yuan Huang, Po-Jung Chen, Jaw-Yuan Wang. Efficacy and safety of first-line cetuximab therapy for older patients (aged ≥ 70 years) with RAS wild-type metastatic colorectal cancer: a nationwide real-world study. American Journal of Cancer Research. 2025 Jul 15;15(7):3093–3105. (SCI)(IF:2.9)
8. Yi-Syuan Lin, Ya-Chuan Tsai, Chia-Jung Li, Tzu-Tang Wei , Jui-Lin Wang, Bo-Wen Lin , Ya-Na Wu, Shang-Rung Wu, Shin-Chih Lin, Shih-Chieh Lin.

Overexpression of NUDT16L1 sustains proper function of mitochondria and leads to ferroptosis insensitivity in colorectal cancer. Redox Biology. 2024 Nov; 77:103358. (SCI)(IF:10.7)

9. Shiang-Jie Yang, Sheng-Tsung Chang , Kung-Chao Chang, Bo-Wen Lin,Kwang-Yu Chang, Yao-Wen Liu, Ming-Derg Lai, Liang-Yi Hung. Neutralizing IL-16 enhances the efficacy of targeting Aurora-A therapy in colorectal cancer with high lymphocyte infiltration through restoring anti-tumor immunity. Cell Death Disease. 2024 Jan 30;15(1):103.
10. Tsai-Sheng Yang, Hong-Hwa Chen, Lin Bo-Wen, Tae Won Kim, Jong GwangKim, Joong Bae Ahn, Myung-Ah Lee, Johnson Lin, Gwo Fuang Ho, Le Tuan Anh, Sally Temraz, Matthew Burge, Clarinda Chua, Jason Huang, Young Suk Park. Prospective, open-label, and observational study of cetuximab for metastatic colorectal carcinoma: The OPTIM1SE study. Asia-Pacific Journal of Clinical Oncology. 2023 Dec ; 19(6):672-680. (SCI)(IF:1.9)

11. Chou-Chen Chen, Shih-Ching Chang, Yu-Yao Chang, Bo-Wen Lin, Hong-HwaChen, Yao-Yu Hsieh, Hung-Chih Hsu, Meng-Che Hsieh, Tao-Wei Ke, Feng-Che Kuan, Chih-Chien Wu, Wei-Chen Lu, Yu-Li Su, Yi-Hsin Liang, Joe-Bin Chen, Hsuan-Yuan Huang, Hsiang-Lin Tsai, Jaw-Yuan Wang. Survival benefit of metastasectomy in first-line cetuximab therapy in patients with RAS wild-type metastatic colorectal cancer: a nationwide registry. American Journal of Cancer Research. 2023 Dec 15;13(12):6333-6345. (SCI)(IF:3.6)
12. Chih-Jie Shen, Ren-Hao Chan, Bo-Wen Lin, Nien-Chi Li, Ying-Hsuan Huang,Wen-Chang Chang, Ben-Kuen Chen. Oleic acid-induced metastasis of KRAS/p53-mutant colorectal cancer relies on concurrent KRAS activation and IL-8 expression bypassing EGFR activation. Theranostics. 2023 Aug 21 ; 13(13):4650-4666. (SCI)(IF:12.4)
13. Chung-Ta Lee, Chien-An Chu, Yu-Ming Wang, Yi-Wen Wang, Yi-Lin Chen, Chung-Liang Ho, Yu-Min Yeh, Peng-Chan Lin, Bo-Wen Lin, Po-Chuan Chen,Shang-Hung Chen, Ren-Hao Chan, Chen Chang, Nan-Haw Chow. Dual role of sprouty2 as an inhibitor of RAS/ERK-driven proliferation and a promoter of cancer invasion in KRAS wild-type colorectal cancer. Molecular Carcinogenesis. 2023 Jul ; 62(7):951-962. (SCI)(IF:5.139)
14. Yu-Tang Chang, Chou-Chen Chen, Shih-Ching Chang, Yu-Yao Chang, Bo-WenLin, Hong-Hwa Chen, Yao-Yu Hsieh , Hung-Chih Hsu, Meng-Che Hsieh, Feng-Che Kuan, Chih-Chien Wu, Wei-Chen Lu, Yu-Li Su, Yi-Hsin Liang, Joe-Bin Chen, Shuan-Yuan Huang, Ching-Wen Huang, Jaw-Yuan Wang. Efficacy and Safety of a Parenteral Nutrition Program for Patients with RAS Wild-Type Metastatic Colorectal Cancer Administered First-Line Cetuximab Plus Chemotherapy: A Propensity Score Matching Study. Nutrients. 2023 Jun30;15(13):2971. (SCI)(IF:5.9)

15. Po-Chuan Chen, Yu-Min Yeh, Chun-Ting Chu, Pei-Fang Su, Pin-Hsuan Chiu,Bo-Wen Lin, Shang-Hung Chen, Peng-Chan Lin, Chung-Ta Lee, Helen H WChen, Chien-Chin Chen. HER2 amplification in colorectal cancer with brain metastasis: A propensity score matching study. European Journal of Cancer. 2023 Mar ; 181:62-69. (SCIE)(IF:8.4)
16. Pei-Ling Hsu, Chun-Wei Chien, Yen-An Tang, Bo-Wen Lin, Shih-Chieh Lin,Yi-Syuan Lin, Sih-Yu Chen, H Sunny Sun, Shaw-Jenq Tsai. Targeting BRD3eradicatesnuclearTYRO3-inducedcolorectalcancermetastasis.ScienceAdvances.2023Apr14；9(15):eade3422. doi:10.1126/sciadv.ade3422(SCI)(IF:13.6)

17. Chi-Che Hsieh, Sen-Huei Hsu , Chih-Yu Lin, Hung-Jiun Liaw, Ting-Wei Li, Kuan-Ying Jiang, Nai-Jung Chiang, Shang-Hung Chen, Bo-Wen Lin, Po-ChuanChen, Ren-Hao Chan, Peng-Chan Lin, Yu-Min Yeh, Che-Hung Shen. CHK2 activation contributes to the development of oxaliplatin resistance in colorectal cancer. British Journal of Cancer. 2022 Nov ;127(9):1615-1628 (SCI)(IF:9.089)
18. Bing-Syuan Chung, I-Chuang Liao, Peng-Chan Lin, Shang-Yin Wu, Jui-Wen Kang, Bo-Wen Lin, Po-Chuan Chen, Ren-Hao Chan, Chung-Ta Lee, Meng-RuShen, Shang-Hung Chen and Yu-Min Yeh. PD-L1 Expression in High-Risk Early-Stage Colorectal Cancer—Its Clinical and Biological Significance in Immune Microenvironment. International Journal of Molecular Science. 2022 Oct 31 ; 23(21), 13277. (SCI)(IF:6.208)
19. Po-Chuan Chen, Yu-Min Yeh, Bo-Wen Lin, Ren-Hao Chan, Pei-Fang Su, Yi-Chia Liu, Chung-Ta Lee, Shang-Hung Chen, Peng-Chan Lin. A Prediction Model for Tumor Recurrence in Stage II-III Colorectal Cancer Patients: From a Machine Learning Model to Genomic Profiling. Biomedicines. 2022 Feb 1 ;10(2):340. (SCI)(IF:6.081)

20. Ren-Hao Chan, Po-Chuan Chen, Yu-Min Yeh , Bo-Wen Lin , Kai-Di Yang,Meng-Ru Shen, Peng-Chan Lin. The Expression Quantitative Trait Loci in Immune Response Genes Impact the Characteristics and Survival of Colorectal Cancer. Diagnostics.2022 Jan 26 ; 12(2):315(SCI)(IF:3.706)
21. Yi-Hsuan Huang, Peng-Chan Lin, Wu-Chou Su, Ren-Hao Chan, Po-Chuan Chen, Bo-Wen Lin, Meng-Ru Shen, Shang-Hung Chen and Yu-Min Yeh.Association between Altered Oncogenic Signaling Pathways and OverallSurvival of Patients with Metastatic ColorectalCancer. Diagnostics. 2021 Dec 5；11 (12):2308(SCI)(IF:3.706)
22. Kun-Huei Yeh, Tsai-Sheng Yang, Tzu-Chi Hsu, William Tzu-Liang Chen,Hong-Hwa Chen, Hao-Wei Teng, Bo-Wen Lin, Feng-Che Kuan, Feng-Fan

Chiang, Chi-Wei Duann,    Ying-Shiuan Li, Meng-Ting Lin, Sabine Fiala-Buskies, Michel Ducreux, Jaw-Yuan Wang. Real-world evidence of the safety and effectiveness of regorafenib in Taiwanese patients with metastatic colorectal cancer: CORRELATE Taiwan. Journal of the Formosan Medical Association.2021 Nov；120(11):2023-2031 (SCI)(IF:3.008)

23. Hong-Hwa Chen, Tao-Wei Ke, Ching-Wen Huang, Jeng-Kae Jiang, Chou-Chen Chen, Yao-Yu Hsieh, Hao-Wei Teng, Bo-Wen Lin, Yi-Hsin Liang,Yu-Li Su1,Hung-Chih Hsu, Feng-Che Kuan, Yenn-Hwei Chou, Johnson Lin, Ben-Ren Lin, Yu-Yao Chang and Jaw-Yuan Wang. Taiwan Society of Colon and RectalSurgeons Consensus on mCRC Treatment. Frontiers in Oncology. 2021 Nov 15；11:764912. (SCI)(IF:6.244)
24. Peng-Chan Lin, Yu-Min Yeh, Hui-Ping Hsu, Ren-Hao Chan, Bo-Wen Lin, Po-Chuan Chen, Chien-Chang Pan, Keng-Fu Hsu, Jenn-Ren Hsiao, Yan-Shen Shan, Meng-Ru Shen. Comprehensively Exploring the Mutational Landscape and Patterns of Genomic Evolution in Hypermutated Cancers. Cancers. 2021 Aug 26；13(17):4317. (SCI)(IF:6.639)

25. Peng-Chan Lin, Yu-Min Yeh, Ren-Hao Chan, Bo-Wen Lin, Po-Chuan Chen,Chien-Chang Pan, Meng-Ru Shen. Sequential and co-occurring DNA damage response genetic mutations impact survival in stage III colorectal cancer patients receiving adjuvant oxaliplatin-based chemotherapy. BMC Cancer. 2021 Mar 2;21(1):217. (SCI)(IF=4.430)
26. Szu-Jung Chen, Li-Hsien Chen, Yu-Min Yeh, Chou-Ching K Lin, Peng-Chan Lin, Han-Wei Huang, Meng-Ru Shen, Bo-Wen Lin, Jeng-Chang Lee, Cheng-Che Lee, Yueh-Feng Lee, Huai-Chueh Chiang, Jang-Yang Chang. Targeting Lysosomal Cysteine Protease Cathepsin S Reveals Immunomodulatory Therapeutic Strategy for Oxaliplatin-Induced Peripheral Neuropathy.Theranostics. 2021 Mar 4；11(10):4672-4687 (SCI)(IF:8.579)
27. Ren-Hao Chan, Peng-Chan Lin, Shang-Hung Chen, Shao-Chieh Lin, Po-Chuan Chen, Bo-Wen Lin, Meng-Ru Shen, Yu-Min Yeh. Clinical Utility of a Cell-FreeDNA Assay in Patients With Colorectal Cancer. Frontiers in Oncology. 2021 Mar 19;11:589673. (SCI)(IF:6.244)
28. Chung-Ta Lee, Nan-Haw Chow, Yi-Lin Chen, Chung-Liang Ho, Yu-Min Yeh, Shao-Chieh Lin, Peng-Chan Lin, Bo-Wen Lin, Chien-An Chu, Hung-Wen Tsai,Jenq-Chang Lee. Clinicopathological features of mismatch repair protein expression patterns in colorectal cancer. Pathology Research and Practice. 2021 Jan; 217:153288. (SCI)(IF:3.250)
29. R-H Chan, S-C Lin, P-C Chen, W-T Lin, C-H Wu, J-C Lee, B-W Lin.Management of colorectal anastomotic stricture with multidiameter balloon dilation: long-term results. Techniques in Coloproctology. 2020 Dec ; 24(12):1271-1276 (SCI)(IF=2.721) (Corresponding author)Wei-Li Huang, Ying-Yuan Chen, Chao-Chun Chang, Yi-Ting Yen, Wu-Wei Lai,Bo-Wen Lin, Jenq-Chang Lee, Yau-Lin Tseng. Pulmonary metastasectomy for

colorectal cancer: Prognosis analysis disaggregated by the origin of the primary tumor. Asian Journal of Surgery. 2020 Nov; 43(11):1069-1073. (SCI)(IF=2.767)

31. Peng-Chan Lin, Yu-Min Yeh, Bo-Wen Lin, Shao-Chieh Lin, Ren-Hao Chan, Po-Chuan Chen, Meng-Ru Shen. Intratumor Heterogeneity of MYO18A and FBXW7 Variants Impact the Clinical Outcome of Stage III Colorectal Cancert the Clinical Outcome of Stage III Colorectal Cancer. Frontiers in Oncology.2020 Oct 29 ; 10:588557. Doi:10.3389(SCI)(IF:4.848)
32. Yu-Min Yeh, Peng-Chan Lin, Chung-Ta Lee, Shang-Hung Chen, Bo-Wen Lin, Shao-Chieh Lin, Po-Chuan Chen, Ren-Hao Chan, Meng-Ru Shen.

Treatment monitoring of colorectal cancer by integrated analysis of plasmaconcentration and sequencing of circulating tumor DNA. Molecular Cancer. 2020 Oct 26 ; 19(1):150. doi: 10.1186(SCI)(IF:15.302)

33. Wei-Ting Lin, Ren-Hao Chan, Chun-Hsien Wu, Po-Chuan Chen, Shao-Chieh Lin, Jenq-Chang Lee, Bo-Wen Lin. Prognostic Factors for Locally Advanced Stage IV Colorectal Cancer. Journal of Society of Colon and Rectal Surgeons,R.O.C. 2020 Sep;31(3):159-167(Corresponding author)
34. Chih-Jie Shen, Kwang-Yu Chang, Bo-Wen Lin, Wei-Ting Ling, Che-Min Su,Jhih-Peng Tsai, Yu-Han Liao, Liang-Yi Hung, Wen-Chang Chang, & Ben-Kuen Chen. Oleic acid-induced NOX4 is dependent on ANGPTL4 expresssion to promote human colorecl cancer metastasis. Theranostics. 2020 May30 ;10(16):7083-7099. Doi:10.7150/thno.44744(SCI)(IF:8.063)

35. Chien-Hsien Lai , Ruo-Yu Chen , Hsing-Pang Hsieh , Shaw-Jenq Tsai , Kung-Chao Chang , Chia-Jui Yen , Yu-Chuan Huang , Yao-Wen Liu , Jenq-Chang Lee , Yi-Chien Lai , Liang-Yi Hung , Bo-Wen Lin. A Selective Aurora-A 5'-

UTR siRNA Inhibits Tumor Growth and Metastasis. Cancer Lett. 2020 Mar 1;472:97-107. doi: 10.1016(SCI)(IF:6.508)(Corresponding author)

36. Chun-Hsien Wu, Yi-Ting Yen, Chih-Jung Wang, Tsung-Han Yang, Kuo-Shu Hung, Wei-Ting Lin, Ren-Hao Chan, Bo-Chuan Chen, Shao-Chieh Lin, Jenq-Chang Lee, Bo-Wen Lin. Outcomes of Blunt Colonic Injury in Patients with Polytrauma. Journal of Society of Colon and Rectal Surgeons,R.O.C. 2019 Dec； 30(4):135-141(Corresponding author)
37. Yu-Min Yeh, Chun-Hui Lee, Shang-Hung Chen, Chung-Ta Lee, Yi-Lin Chen, Bo-Wen Lin, Shao-Chieh Lin, Ren-Hao Chan, Jenq-Chang Lee, Meng-Ru Shen, Peng-Chan Lin. Comprehensive assessment of HER2 alteration in a colorectal cancer cohort: from next-generation sequencing to clinical significance. Cancer Management and Research. 2019 Aug 20;11:7867-7875. (SCI)(IF=3.989)
38. Chien-An Chu, Chung-Ta Lee, Jenq-Chang Lee, Yi-Wen Wang, Ching-Tang Huang, Sheng-Hui Lan, Peng-Chan Lin, Bo-Wen Lin, Yu-Feng Tian, Hsiao-Sheng Liu, Nan-Haw Chow. MiR-338-5p promotes metastasis of colorectal cancer by inhibition of phosphatidylinositol 3-kinase, catalytic subunit type 3-mediated autophagy pathway. EBioMedicine. 2019 May ;43:270-281. https://doi.org/10.1016/j.ebiom.2019.04.010(SCI)(IF:6.183)
39. Yu-Chu Wang, Kung-Chao Chang, Bo-Wen Lin , Jenq-Chang Lee , Chien-Hsien Lai , Li-Jyuan Lin, Yun Yen, Chang-Shen Lin, Shiang-Jie Yang, Peng-Chan Lin, Chung- Ta Lee and Liang-Yi Hung. The EGF/hnRNP Q1 axis is involved in tumorigenesis via the regulation of cell cycle-related genes.Experimental & Molecular Medicine. 2018 Jun 6;50(6):70. doi:0.1038/s12276-018-0101-6. (SCI)(IF:5.584)

40. Wei-Ting Lin, Ren-Hao Chan, Shao-Chieh Lin, Jenq-Chang Lin, Bo-Wen Lin,Po-Chuan Chen. Ligation of intersphincteric fistula tract(LIFT) for anal fistula and abscess : a single surgeon experience. Journal of Society of Colon and Rectal Surgeons,R.O.C. 2018 Jun.1 ;29(2):106-113

41. Chun-Hsien Wu, Bo-Wen Lin, Ren-Hao Chan, Bo-Chuan Chen, Jenq-Chang Lee, Shao-Chieh Lin. Comparison of Conventional and Starion Hemorrhoidectomy for Prolapsed Hemorrhoids. Journal of Society of Colon and Rectal Surgeons,R.O.C. 2017 Sep.28(3):140-146
42. Pei-Chi Hou,Yo-Hua Li, Shih-Chieh Lin, Shau-Chieh Lin, Jenq-Chang Lee, Bo-Wen    Lin, Jing-Ping Liou, Jang-Yang Chang, Ching-Chuan Kuo, Yi-Min Liu,H.Sunny Sun, and Shaw-Jenq Tsai. Hypoxia-Induced Downregulation of DUSP-2Phosphatase Drives Colon Cancer Stemness. Cancer Research.2017 Aug 15;77(16):4305-4316. doi: 10.1158/0008-5472.CAN-16-2990. Epub 2017Jun 26. (SCI)(IF:9.122)
43. Chung-Ta Lee,Yu-Chuan Huang,Liang-Yi Hung,Nan-Haw Chow,Pei-Fang Su,Chung-Liang Ho,Hung-Wen Tsai,Yi-Lin Chen,Shao-Chieh Lin, Bo-Wen Lin,Peng-Chan Lin,Jenq-Chang Lee. Serrated adenocarcinoma morphology in colorectal mucinous adenocarcinoma is associated with improved patient survival. Oncotarget. 2017 May 23; 8(21): 35165–35175(SCI).(IF:5.168)
44. Wei-Ting Lin, Ren-Hao Zhan, Bo-Chuan Chen, Shao-Chieh Lin, Jenq-Chang Lee, Bo-Wen Lin. Transverse colonic tubular duplication in young adult present with epigastric pain – case report. Taiwan Surgical Association. 2017 Mar.19
45. Chien-Hsien Lai, Yu-Chuan Huang , Jenq-Chang Lee , Joseph Ta-Chien Tseng, Kung-Chao Chang, Yen-Ju Chen, Nai-Jhu Ding, Pao-Hsuan Huang, Wen-ChangChang, Bo-Wen Lin, Ruo-Yu Chen, Yu-Chu Wang, Yi-Chien Lai and Liang-Yi Hung. Translational upregulation of Aurora-A by hnRNP Q1 contributes to cell proliferation and tumorigenesis in colorectal cancer. Cell Death & Disease.2017 Jan.; 8(1):e2555. doi: 10.1038/cddis.2016.479.(SCI)(IF:5.965)

46. Ren-Hao Chan, Bo-Wen Lin, Shao-Chieh Lin, Jenq-Chang Lee. Thiersch Procedure for Rectal Prolapse: Experiences From a Single Institution.

International surgery . 2017 Jan 1；102:10-14. doi:10.9738(SCI)(IF=0.576)

47. Wei-Ting Lin,Ren-Hao Chan,Bo-Chuan Chen,Shao-Chieh Lin,Jenq-Chang Lee,Bo-Wen Lin. Applying Endoanal Ultrasound for Anal Fistula: A Single Instrument Approach. Journal of Society of Colon and Rectal Surgeons,R.O.C. 2016 Dec ; 27(4):148-154.(Corresponding author)

48. Yu-Chuan Huang, Chung-Ta Lee, Jenq-Chang Lee, Yao-Wen Liu, Ying-Jen Chen, Joseph T. Tseng, Jui-Wen Kang, Bor-Shyang Sheu, Bo-Wen Lin, Liang-Yi Hung, Epigenetic silencing of miR-137 contributes to early colorectal carcinogenesis by impaired Aurora-A inhibition. Oncotarget.2016 Nov. 22;7(47):76852-76866. (SCI) (Corresponding author)(IF:5.168)
49. Chien Chun-Wei, Hou Pei-Chi, Wu Han-Chung, Chang Yu-Ling, Lin Shih-Chieh, Lin Shao-Chieh, Lin Bo-Wen, Lee Jenq-Chang, Chang Yu-Jia, Sun H.-Sunny, Tsai Shaw-Jenq. Targeting TYRO3 inhibits epithelial-mesenchymal transition and increases drug sensitivity in colon cancer. Oncogene. 2016 Nov.10;35(45):5872-5881. doi: 10.1038/onc.2016.120. Epub 2016 May 2. (SCI)(IF:7.519)
50. Ren-Hao Chan, Po-Chuan Chen, Shao-Chieh Lin, Jenq-Chang Lee, Bo-Wen Lin. Prognostic Factors of Early Metastasis in Stage III Colorectal Cancer.

ournal of Society of Colon and Rectal Surgeons,R.O.C. 2016 Mar. ;27(1):23-28

51. Ren-Hao Chan, Po-Chuan Chen, Shao-Chieh Lin, Bo-Wen Lin, Jenq-Chang Lee.Incidental Appendectomy is Unnecessary in Colorectal Surgery: The Experience of a Single Center. Journal of Society of Colon and Rectal Surgeons,R.O.C. 2015 Jun.6 ; 26(2):71-75

52. Jui-Wen Kang, Shao-Chieh Lin, Po-Chuan Chen, Bo-Wen Lin, Chung-Ta Lee,Chiung- Yu Chen, Shu-Chu Shiesh, Jenq-Chang Lee, Xi-Zhang Lin. Role of vitam D and local vitamin D receptor expression in colon carcinogenesis.Journal of Gastroenterology and Hepatology. 2015 ; 30(Suppl. 4):104(SCI)(IF:3.452)
53. Hong-Hwa Chen, William Tzu-Liang Chen, Hsin-Chung Lee, Jen-Kou Lin, Chuan-Yin Fang, Yenn-Hwei Chou, Peng-Chan Lin, Bo-Wen Lin, Chi-Chou Huang, Chung-Hung Yeh, Hsi-Hsien Hsu, Hung-Chang Chen, Wen-Chien Ting, Ming-Chin Yang, Elise Chia-Hui Tan. Health-related quality of life and cost comparison of adjuvant capecitabine versus 5-ftuorouracil/leucovorin in stage III colorectal cancer patients. Quality of Life Research . 2015 Feb ; 24(2):473–484.(SCI)(IF:2.344)
54. Bo-Wen Lin, Yu-Chu Wang, Pey-Yi Chang-Liao, Ya-Ju Lin, Shu-TingYang,Jen-Hui Tsou, Kung-Chao Chang, Yao-Wen Liu, Joseph T. Tseng, Chung-Ta Lee, Jenq-Chang Lee and Liang-Yi Hung. Overexpression of Aurora-C impaired the spindle checkpoint by promoting the degradation of Aurora-B. Cell Death and Disease .2014 Mar 6 ; 5(3):e1106.(SCI)(Fist author)(IF:5.965)
55. Pao-Lin Kuo,Yung-Ling Huang,Christine Chin-Jung Hsieh,Jenq-Chang Lee,Bo-Wen Lin, Liang-Yi Hung. STK31 Is a Cell-Cycle Regulated Protein That Contributes to the Tumorigenicity of Epithelial Cancer Cells. PLOS ONE.2014 Mar 25;9(3):e93303. (SCI)(IF:2.806)

56. Po-Chuan Chen, Jenq-Chang Lee, Bo-Wen Lin, Shao-Chieh Lin .Prognostic Factors for Colorectal Carcinoids. Journal of Society of Colon and Rectal Surgeons,R.O.C. 2013 Sep ;24(3):65-71.
57. SC Lin, PC Chen, CT Lee, HM Tsai, PC Lin, Helen, H.W. Chen, YH Wu, B-W Lin, WP Su, JC Lee. Routine defunctioning stoma after chemoradiation and total mesorectal excision: a single-surgeon experience. World Journal of Gastroenterology . 2013 Mar 21;19(11):1797-1804.(SCI)(IF:3.365)
58. PC Chen, SC Lin, JC Lee, TH Lai, B-W Lin. Primary Adenocarcinoma of the Appendix. Journal of Society of Colon and Rectal Surgeons, Taiwan. 2012 Dec;23(4):168-174. (Corresponding author)
59. Po-Chuan Chen, Wen-Chau Chen, Sheau-Chiou Chao, Bo-Wen Lin, Shao-Chieh Lin, Chia-Jung Chen.Jenq-Chang Lee. Six primary cancers in one lynch syndrome patient with chronic arsenic exposure. Journal of Surgical Oncology . 2012 Mar; 105(3):329-330.(SCI)(IF:2.993)
60. PC Chen, SC Lin, B-W Lin, JC Lee. A Comparison between     Hartmann'sProcedure and Primary Anastomosis    with Defunctioning Stoma in Complicated Left-Sided Colonic Perforation. Journal of Society of Colon and Rectal Surgeons,R.O.C. 2012 Mar;23(1):13-18. (Corresponding author)
61. Tsou JH, Chang KC, Chang-Liao PY, Yang ST, Lee CT, Chen YP, Lee YC, LinBW, Lee JC, Shen MR, Chuang CK, Chang WC, Wang JM. Hung LY,

Aberrantly expressed AURKC enhances the transformation and tumourigenicity of epithelial cells. Journal of Pathology . 2011 Oct ; 225(2):243-254.(SCI)(IF:6.894)C-W Lu, S-C Lin, C-W Chien, S-C Lin, C-T Lee, B-W Lin, J-C Lee, S-J Tsai,

Overexpression of pyruvate dehydrogenase kinase 3 increases drug resistance and early recurrence in colon cancer. American Journal of Pathology .2011 Sep; 179(3):1405-1414.(SCI) (IF:3.491)

63. C-T Weng , T-J Chung, M-F Liu, M-Y Weng, C-H Lee, J-Y Chen, A-B Wu, B-W Lin, C-Y Luo, S-C Hsu, B-F Lee, H-M Tsai, S-C Chao, J-Y Wang, T-Y

Chen, C-W Chen, H-Y Chang, C-R Wang. A retrospective study of pulmonary infarction in patients with systemic lupus erythematosus from southern Taiwan.Lupus .2011 Jun 21;20(8):876-885.(SCI)(IF:2.454)

64. SC Lin, BW Lin, WW Lai,YL Tseng,MH WU.Surgical      Management of Pulmonary Metastases of Colorectal Cancer. Journal of Society of Colon and Rectal Surgeons,R.O.C.2010;21:130-137
65. Luo Chwan-Yau, Lai Chao-Han, Wen Jih-Sheng, Lin Bo-Wen. Secondary aortocolic fistula: case report and review of the literature. Annals of Vascular Surgery . 2010 Feb ; 24(2):256. e5-256. e12.(SCI)(IF:1.145)
66. Lai CH, Tseng JT, Lee YC, Chen YJ Lee JC, Lin Bo-Wen, Huang TC, Liu YW, Leu TH, liu YW, Chen YP, Chang WC, Hung LY. Translational up-regulatuion of Aurora-A in EGFR-overexpressed cancer. Journal of Cellular and Molecular Medicine . 2010 Jun ;14(6B):1520-1531.(SCI)(IF:4.499)
67. Hong-Ming Tsai, Bo-Wen Lin, Ying-Tai Jin, Chia-Tse Weng, Chrong-Reen Wang, Behc¸et. Disease Complicated by a Perforated Ileal Ulcer Presenting as an Acute Abdominal Emergency.JCR: Journal of Clinical Rheumatology . 2009; 15(6):321. (SCI)(IF:1.322)
68. Tsai Wen-Ping, Shieh Shyh-Jou,  Lin Bo-Wen. Extensive perineal and